Expression and significance of interleukin-17 in rejection after kidney transplantation

doi:10.3969/j.issn.2095-4344.2014.51.014

Abstract

Abstract:

BACKGROUND: Interleukin-17 is a potent inflammatory cytokine, which has been greatly reported in acute rejection research but little in chronic rejection or acute and chronic rejection research.

OBJECTIVE: By studying the correlation between interleukin-17 and renal allograft rejection, to explore the asociation between interleukin-17 and rejections.

METHODS: In accordance with the inclusion criteria strictly, health physical examination persons (15 caess) and kidney transplantation recipients (47 caess) were choosed and divided into four groups: normal group (15 cases), stable renal function group (20 cases), acute rejection group (15 cases), and chronic rejection group (12 cases). The relative expression levels of interleukin-17 mRNA in peripheral blood mononuclear cells of these four groups were detected by real-time fluorescence quantitative PCR. Then differences between four groups were compared and the correlations with the serum creatinine and the rejection time were analyzed.

RESULTS AND CONCLUSION: The expression levels of interleukin-17 mRNA in the acute rejection and stable renal function groups were signfiicantly different from that in the normal group. The expression level of interleukin-17 mRNA in the chronic rejection group was increased by 2.89 times, showing a significant difference from the stable group (P < 0.01). In the acute and chronic rejection groups, the expression level of interleukin-17 mRNA had no significant correlation with serum creatinine level and postoperative rejection time. These findings indicate that interleukin-17 is of significance in renal allograft rejection.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: interleukins, graft rejection, kidney transplantation, lymphocytes

CLC Number:

R318

Sun Shu, Li Zhou-li, Cai Ming, Wang Qiang2 Jin Hai-long, Chen Chang-qing, Liu Zhi-jia, Kong Xiang-rui, Li Cong-ran, Shi Bing-yi. Expression and significance of interleukin-17 in rejection after kidney transplantation[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(51): 8275-8280.

Figures/Tables 3

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